Neuropathological changes in essential tremor: 33 cases compared with 21 controls
نویسندگان
چکیده
منابع مشابه
Structural differences in impaired verbal fluency in essential tremor patients compared to healthy controls
OBJECTIVE We wanted to identify differences in grey and white matter in essential tremor patients compared to controls in the non-motor domain, using the example of impaired verbal fluency. BACKGROUND A disturbance of verbal fluency in essential tremor patients compared to healthy controls is behaviorally well described. METHODS Voxel-based morphometry and tract-based spatial statistics wer...
متن کاملFunctional Aspects of Gait in Essential Tremor: A Comparison with Age-Matched Parkinson’s Disease Cases, Dystonia Cases, and Controls
BACKGROUND An understanding of the functional aspects of gait and balance has wide ramifications. Individuals with balance disorders often restrict physical activity, travel, and social commitments to avoid falling, and loss of balance confidence, itself, is a source of disability. We studied the functional aspects of gait in patients with essential tremor (ET), placing their findings within th...
متن کاملRelationship between blood harmane and harmine concentrations in familial essential tremor, sporadic essential tremor and controls.
INTRODUCTION Harmane, a potent tremor-producing β-carboline alkaloid, may play a role in the etiology of essential tremor (ET). Blood harmane concentrations are elevated in ET cases compared with controls yet the basis for this elevation remains unknown. Decreased metabolic conversion (harmane to harmine) is one possible explanation. Using a sample of >500 individuals, we hypothesized that defe...
متن کاملSensorineural Hearing Loss in Non-depressed Essential Tremor Cases and Controls: A Clinical and Audiometric Study
BACKGROUND Patients with essential tremor (ET) have an increased prevalence of hearing loss, and depression is a confounding issue for both conditions. We assessed hearing loss in non-depressed ET patients and controls using a questionnaire and audiometric tests. METHODS The study included 34 patients with ET and 45 volunteers were included. Both groups were asked if they had hearing loss, an...
متن کاملElevated brain harmane (1-methyl-9H-pyrido[3,4-b]indole) in essential tremor cases vs. controls.
BACKGROUND Harmane (1-methyl-9H-pyrido[3,4-β]indole), a potent neurotoxin that has tremor-producing properties in animal models, is present in many foods; although we have demonstrated a difference in tissue harmane concentrations in ET cases vs. controls, all work to date has involved blood samples. OBJECTIVES We quantified harmane concentrations in human cerebellum, a brain region of partic...
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ژورنال
عنوان ژورنال: Brain
سال: 2007
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awm266